Lab Members Publications

Previous Publications



Identification of proximal SUMO-dependent interactors using SUMO-ID

Orhi Barroso-Gomila, Fredrik Trulsson, Veronica Muratore, Iñigo Canosa, Laura Merino-Cacho, Ana Rosa Cortazar, Coralia Perez, Mikel Azkargorta, Ibon Iloro, Arkaitz Carracedo, Ana M Aransay, Felix Elortza, Ugo Mayor, Alfred C. O. Vertegaal, Rosa Barrio, James D. Sutherland









Mol Metab. 2021 Jun 18;53:101275. doi: 10.1016/j.molmet.2021.101275.

Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis

Serrano-Maciá M, Simón J, González-Rellan MJ, Azkargorta M, Goikoetxea-Usandizaga N, Lopitz-Otsoa F, De Urturi DS, Rodríguez-Agudo R, Lachiondo-Ortega S, Mercado-Gomez M, Gutiérrez de Juan V, Bizkarguenaga M, Fernández-Ramos D, Buque X, Baselli GA, Valenti LVC, Iruzubieta P, Crespo J, Villa E, Banales JM, Avila MA, Marin JJG, Aspichueta P, Sutherland J, Barrio R, Mayor U, Elortza F, Xirodimas DP, Nogueiras R, Delgado TC, Martínez-Chantar ML

PMID: 34153521


Front Cell Dev Biol. 2021 Apr 1;9:624089. doi: 10.3389/fcell.2021.624089.

LUZP1 controls cell division, migration and invasion through regulation of the actin cytoskeleton

Bozal-Basterra L, Gonzalez-Santamarta M, Muratore V, Martín-Martín N, Ercilla A, Rodríguez JA, Carracedo A, Sutherland JD, Barrio R.

PMID: 33869174










International Journal of Molecular Sciences 21(23):9043.

Multi-omics integration highlights the role of ubiquitination in CCl4-induced liver fibrosis

Mercado-Gómez M, Lopitz-Otsoa F, Azkargorta M, Marina Serrano-Maciá , Sofia Lachiondo-Ortega , Naroa Goikoetxea-Usandizaga, Rubén Rodríguez-Agudo , David Fernández-Ramos , Maider Bizkarguenaga, Virginia Gutiérrez-de Juan , Benoît Lectez , Kerman Aloria, Jesus M Arizmendi,  Jorge Simon , Cristina Alonso, Juan J Lozano , Matias A Avila , Jesus M Banales , Jose J G Marin , Naiara Beraza , José M Mato , Felix Elortza , Rosa Barrio , James D Sutherland , Ugo Mayor , Maria L Martinez-Chantar *, Teresa C Delgado *

PMID: 33261190



Elife. 2020 Jun 18;9:e55957. doi: 10.7554/eLife.55957.

LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome.

Bozal-Basterra L, Gonzalez-Santamarta M, Muratore V, Bermejo-Arteagabeitia A, Da Fonseca C, Barroso-Gomila O, Azkargorta M, Iloro I, Pampliega O, Andrade R, Martín-Martín N, Branon TC, Ting AY, Rodríguez JA, Carracedo A, Elortza F, Sutherland JD, Barrio R.

PMID: 32553112









Open Biol. 2020 May;10(5):200054. doi: 10.1098/rsob.200054. Epub 2020 May 6.

SUMOylation in the control of cholesterol homeostasis.

Talamillo A, Ajuria L, Grillo M, Barroso-Gomila O, Mayor U, Barrio R. 

PMID: 32370667











J Clin Invest. 2020 Jul 1;130(7):3848-3864. doi: 10.1172/JCI130379.

HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis.

Palomo-Irigoyen M, Pérez-Andrés E, Iruarrizaga-Lejarreta M, Barreira-Manrique A, Tamayo-Caro M, Vila-Vecilla L, Moreno-Cugnon L, Beitia N, Medrano D, Fernández-Ramos D, Lozano JJ, Okawa S, Lavín JL, Martín-Martín N, Sutherland JD, de Juan VG, Gonzalez-Lopez M, Macías-Cámara N, Mosén-Ansorena D, Laraba L, Hanemann CO, Ercolano E, Parkinson DB, Schultz CW, Araúzo-Bravo MJ, Ascensión AM, Gerovska D, Iribar H, Izeta A, Pytel P, Krastel P, Provenzani A, Seneci P, Carrasco RD, Del Sol A, Martinez-Chantar ML, Barrio R, Serra E, Lazaro C, Flanagan AM, Gorospe M, Ratner N, Aransay AM, Carracedo A, Varela-Rey M, Woodhoo A.

PMID: 32315290


Biochem Soc Trans. 2020 Apr 29;48(2):463-478. doi: 10.1042/BST20190390.

The role of SUMOylation during development

Talamillo A, Barroso-Gomila O, Giordano I, Ajuria L, Grillo M, Mayor U, Barrio R.

PMID: 32311032


J Exp Med. 2020 Jun 1;217(6). pii: e20191787. doi: 10.1084/jem.20191787.

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

Hermanova I, Zúñiga-García P, Caro-Maldonado A, Fernandez-Ruiz S, Salvador F, Martín-Martín N, Zabala-Letona A, Nuñez-Olle M, Torrano V, Camacho L, Lizcano JM, Talamillo A, Carreira S, Gurel B, Cortazar AR, Guiu M, López JI, Martinez-Romero A, Astobiza I, Valcarcel-Jimenez L, Lorente M, Arruabarrena-Aristorena A, Velasco G, Gomez-Muñoz A, Suárez-Cabrera C, Lodewijk I, Flores JM, Sutherland JD, Barrio R, de Bono JS, Paramio JM, Trka J, Graupera M, Gomis RR, Carracedo A.

PMID: 32219437


J Virol. 2019 Oct 9. pii: JVI.01687-19. doi: 10.1128/JVI.01687-19.

Regulation of the Ebola virus VP24 protein by SUMO.

Vidal S, El Motiam A, Seoane R, Preitakaite V, Bouzaher YH, Gómez-Medina S, San Martín C, Rodríguez D, Rejas MT, Baz-Martínez M, Barrio R, Sutherland JD, Rodríguez MS, Muñoz-Fontela C, Rivas C.

PMID: 31597768


Sumoylation and Ubiquitylation: Current and Emerging Concepts. Caister Academic Publishing

Biotin-based approaches for the study of SUMO and Ubiquitin modifications

Sutherland JD, Barroso O, Barrio R


Cell Death Differ. 2019 Oct 1. doi: 10.1038/s41418-019-0407-5.

Targeting PML in triple negative breast cancer elicits growth suppression and senescence.

Arreal L, Piva M, Fernández S, Revandkar A, Schaub-Clerigué A, Villanueva J, Zabala-Letona A, Pujana M, Astobiza I, Cortazar AR, Hermanova I, Bozal-Basterra L, Arruabarrena-Aristorena A, Crespo JR, Valcarcel-Jimenez L, Zúñiga-García P, Canals F, Torrano V, Barrio R, Sutherland JD, Alimonti A, Martin-Martin N, Carracedo A.

PMID: 31570853





Semin Cell Dev Biol. 2019 Sep;93 special issue

Proteostasis



Semin Cell Dev Biol. 2019 Sep;93:97-99. doi: 10.1016/j.semcdb.2019.04.011. Epub 2019 Apr 21.

Proteostasis: The network behind the networks.

Barrio R, Sutherland JD.

PMID: 31004754



Semin Cell Dev Biol. (2018) pii: S1084-9521(18)30161-7. doi: 10.1016/j.semcdb.2018.10.007.

Impaired proteostasis in rare neurological diseases.

Osinalde N, Duarri A, Ramirez J, Barrio R, de Nanclares GP, Mayor U.

PMID: 30355526







Trends Biochem Sci. 2019 Feb 25. pii: S0968-0004(19)30020-9. doi: 10.1016/j.tibs.2019.01.011. [Epub ahead of print] Review.

Using Ubiquitin Binders to Decipher the Ubiquitin Code.

Mattern M, Sutherland J, Kadimisetty K, Barrio R, Rodriguez MS.

PMID: 30819414

















Trends Biochem Sci. 2019 Feb 15. pii: S0968-0004(19)30007-6. doi: 10.1016/j.tibs.2019.01.007.

PROTEOSTASIS: A European Network to Break Barriers and Integrate Science on Protein Homeostasis.

Dissmeyer N, Coux O, Rodriguez MS, Barrio R; Core Group Members of PROTEOSTASIS.

PMID: 30777377











Circ Heart Fail. (2018) 11(10):e005455. doi: 10.1161/CIRCHEARTFAILURE.118.005455.

Putting the Stress on UFM1 (Ubiquitin-Fold Modifier 1).

Sutherland JD*, Barrio R*.

PMID: 30354403






Cell Death Dis. (2018) 9(10):1041. doi: 10.1038/s41419-018-1096-6.

Integrative analysis of transcriptomics and clinical data uncovers the tumor-suppressive activity of MITF in prostate cancer.

Valcarcel-Jimenez L, Macchia A, Martín-Martín N, Cortazar AR, Schaub-Clerigué A, Pujana-Vaquerizo M, Fernández-Ruiz S, Lacasa-Viscasillas I, Santos-Martin A, Loizaga-Iriarte A, Unda-Urzaiz M, Hermanova I, Astobiza I, Graupera M, Starkova J, Sutherland J, Barrio R, Aransay AM, Carracedo A, Torrano V.

PMID: 30310055


Bioinformatics. 2018 Apr 25. doi: 10.1093/bioinformatics/bty336.s

Cluster Locator, online analysis and visualization of gene clustering.

Pazos Obregón F*, Soto P, Lavín JL, Cortázar AR, Barrio R, Aransay AM, Cantera R.

PMID: 29701747


Human Molecular Genetics (2018) 27(11):1955-1971. doi: 10.1093/hmg/ddy103.

Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome.

Ramirez J, Lectez B, Osinalde N, Sivá M, Elu N, Aloria K, Procházková M, Perez C, Martínez-Hernández J, Barrio R, Grantz Šašková K, Arizmendi JM and Mayor U*

PMID: 29788202



The American Journal of Human Genetics (2018), 102, 249–265. doi: 10.1016/j.ajhg.2017.12.017.

Truncated SALL1 impedes primary cilia function in Townes-Brocks Syndrome.

Bozal-Basterra L, Martín-Ruíz I, Pirone L, Liang Y, Sigurdsson JO, Gonzalez-Santamarta M, Giordano I, Gabicagogeascoa E, de Luca A, Rodríguez JA, Wilkie AOM, Kohlhase J, Eastwood D, Yale C, Olsen JV, Rauchman M, Anderson KV, Sutherland JD*, Barrio R*

PMID: 29395072





Frontiers in Neuroscience (2018) 11:732. doi: 10.3389/fnins.2017.00732.

Drosophila melanogaster White Mutant w1118 undergo retinal degeneration

Ferreiro MJ*, Pérez C, Ruiz S, Marchesano M, Ruiz S, Caputi A, Aguilera P, Barrio R, Cantera R.

PMID: 29354028


Cancer Research (2018) 78(2):399-409. doi: 10.1158/0008-5472.CAN-17-0908.

Ligand-independent repression of Trefoil Factor Family by PPARδ is tumour suppressive in prostate cancer.

Martín-Martín N, Arreal L, Fernández-Ruiz S, Castillo-Martin M, Cortazar AR, Torrano V, Zúñiga-García P, Zabala-Letona A, Ugalde-Olano A, Loizaga-Iriarte A, Unda M, Valcárcel-Jiménez L, Arruabarrena-Aristorena A, Piva M, Sánchez-Mosquera P, Aransay AM, Barrio R, Sutherland JD, Carracedo A*

PMID: 29187400


Scientific Reports (2017) 7(1):10740. doi: 10.1038/s41598-017-11354-2

The immunosuppressive effect of the tick salivary protein, Salp15, is persistent and has long-term effects in a murine model of hematopoietic transplant.

Tomás-Cortazar J, Martín-Ruiz I, Barriales D, Pascual-Itoiz MA, Gutierrez de Juan V, Caro-Maldonado A, Merino N, Marina A, Blanco F, Sutherland JD, Barrio R, Rojas A, Martinez-Chantar ML, Carracedo A, Simó C, García-Cañas V, Abecia L, Lavín JL, Aransay AM, Rodríguez H, Anguita J*

PMID: 28878331


Nature (2017) 547(7661): 109-113. doi: 10.1038/nature22964

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.

Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD... Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A*.

PMID: 28658205


Mol Neurodegener. 2017 Apr 11;12(1):29. doi: 10.1186/s13024-017-0170-3

Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.

Martinez A, Lectez B, Ramirez J, Popp O, Sutherland JD, Urbé S, Dittmar G, Clague MJ, Mayor U.

PMID: 28399880



Scientific Reports (2017) 7:40756. doi: 10.1038/srep40756

A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation

Pirone L, Xolalpa W, Sigurðsson JO, Ramirez J, Pérez C, González M, de Sabando AR, Elortza F, Rodriguez MS, Mayor U, Olsen JV, Barrio R*, Sutherland JD.*

PMID: 28098257




Nature Communications (2016) 24(7):12595. doi: 10.1038/ncomms12595

Stratification and therapeutic potential of PML in metastatic breast cancer.

Martín-Martín N, Piva M, Urosevic J, Aldaz P, Sutherland JD, ... Barrio R, Serra V, Vivanco MdM, Matheu A, Gomis RR, Carracedo A*

PMID: 27553708


Nature Cell Biology (2016) 18(6):645-56. doi: 10.1038/ncb3357

The metabolic co-regulator PGC1alpha suppresses prostate cancer metastasis.

Torrano V, Valcarcel-Jimenez L, ... Sutherland JD, ... Barrio R, Velasco G, Pinton P, Cordon-Cardo C, Locasale JW, Gomis RR and Carracedo A*

PMID: 27214280


SUMO (2016) Methods in Molecular Biology, Springer, 1475:109-21. doi: 10.1007/978-1-4939-6358-4_8

Using Biotinylated SUMO-Traps to Analyze SUMOylated Proteins.

Lang V, Da Silva-Ferrada E, Barrio R, Sutherland JD, Rodriguez MS*

PMID: 27631801


SUMO (2016) Methods in Molecular Biology, Springer, 1475:161-9. doi: 10.1007/978-1-4939-6358-4_12

Analysis of SUMOylated Proteins in Cells and In Vivo Using the bioSUMO Strategy.

Pirone L, Xolalpa W, Mayor U, Barrio R*, Sutherland JD*

PMID: 27631805


Proteostasis (2016) Methods in Molecular Biology, Springer, 1449:193-202. doi:10.1007/978-1-4939-3756-1_10

Isolation of ubiquitinated proteins to high purity from in vivo samples.

Ramirez J, Min M, Barrio R, Lindon C*, Mayor U*

PMID: 27613036


Epstein's Inborn Errors of Development (2016) Oxford University Press USA Chapter 33. doi: 10.1093/med/9780199934522.003.0033

SALL1 and the Townes-Brocks syndrome.

Kohlhase J*, Barrio R and Sutherland JD


Epstein's Inborn Errors of Development (2016) Oxford University Press USA Chapter 135. doi: 10.1093/med/9780199934522.003.0135

SALL4 and the Duane Radial-Ray/ Okihiro and Acro-renal-ocular syndromes.

Kohlhase J*, Barrio R and Sutherland JD


Expert Systems With Applications (2016) 55: 403-416. doi:10.1016/j.eswa.2016.02.018

Real-time and decision taking selection of single-particles during automated cryo-EM sessions based on neuro-fuzzy method.

Gil-Carton D*, Zamora M, Sutherland JD, Barrio R, Garrido I, Valle M, Garrido AJ.


Oncotarget (2016) 7(6):6835-46. doi: 10.18632/oncotarget.6899.

Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer.

Royo F, Zuñiga-Garcia P, Torrano V, Loizaga A, Sanchez-Mosquera P, Ugalde-Olano A, González E, Cortazar AR, Palomo L, Fernández-Ruiz S, Lacasa-Viscasillas I, Berdasco M, Sutherland JD, Barrio R, Zabala-Letona A, Martín-Martín N, Arruabarrena-Aristorena A, Valcarcel-Jimenez L, Caro-Maldonado A, Gonzalez-Tampan J, Cachi-Fuentes G, Esteller M, Aransay AM, Unda M, Falcón-Pérez JM*, Carracedo A*.

PMID: 26771841




Molecular Biology & Evolution (2016) 33(2):568-84. doi: 10.1093/molbev/msv242

Evolution of SUMO function and chain formation in insects.

Ureña E, Pirone L, Chafino S, Pérez C, Sutherland JD, Lang V, Rodriguez MS, Lopitz-Otsoa F, Blanco F, Barrio R*, Martin D.*

PMID: 26538142




Nature Communications (2015) 6:7935. doi: 10.1038/ncomms8935

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.

Serra H, Chivite I, Angulo-Urarte A, Soler A, Sutherland JD, Arruabarrena-Aristorena A, Ragab A, Lim R, Malumbres M, Fruttiger M, Potente M, Serrano M, Fabra A, Viñals F, Casanovas O, Bigas A, Carracedo A, Gerhardt H, and Graupera M*

PMID: 26228240


PLoS One (2015) 10(10):e0139083. doi: 10.1371/journal.pone.0139083. eCollection 2015.

Proteomic Analysis of the Ubiquitin Landscape in the Drosophila Embryonic Nervous System and the Adult Photoreceptor Cells.

Ramirez J, Martinez A, Lectez B, Lee SY, Franco M, Barrio R, Dittmar G, Mayor U*

PMID: 26460970


Scientific Reports (2015) 5:14692. doi: 10.1038/srep14692.

Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages

Navasa N, Martin-Ruiz I, Atondo E, Sutherland JD, Angel Pascual-Itoiz M, Carreras-González A, Izadi H, Tomás-Cortázar J, Ayaz F, Martin-Martin N, Torres IM, Barrio R, Carracedo A, Olivera ER, Rincón M, Anguita J.*

PMID:  26419808


Scientific Reports (2015) 5: 12383. doi:10.1038/srep12383.

The steroid hormone ecdysone promotes imaginal discs growth in Drosophila melanogaster.

Herboso L, Oliveira MM Talamillo A, Pérez C, González M, Martin D, Sutherland JD, Shingleton AW, Mirth C and Barrio R.*

PMID: 26198204


PLoS Genetics (2015) 11(8):e1005370. doi: 10.1371/journal.pgen.1005370

The Spalt Transcription Factors Generate the Transcriptional Landscape of the Drosophila melanogaster Wing Pouch Central Region

Organista MF, Martín M, de Celis JM, Barrio R, López-Varea A, Esteban N, Casado M, de Celis JF.*

PMID: 26241320



Journal of Innate Immunity (2015) 7(1):3-10s.

Do the genes of the innate immune response contribute to neuroprotection in Drosophila?

Cantera R*, Barrio R.

PMID: 25115549



Nature Communications (2014) 5:5649.

Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion

Gradilla AC, Gonzalez E, Seijo I, Andrés G, Bischoff M, González-Mendez L, Sánchez V, Callejo A, Ibáñez C, Guerra M, Ortigao-Farias JR, Sutherland JD, Gonzalez M, Barrio R, Falcon-Perez JM, Guerrero I*.

PMID: 25472772


Cell Death and Disease (2014) 5, e1399.

The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T cell activation

Rodriguez MS, Egaña I, Lopitz-Otsoa F, Aillet F, Dorronroso A, Lobato-Gil S, Ferrin I, Sutherland JD, Barrio R, Trigueros C and Lang V*.

PMID: 25165885


PLoS One (2014) 9(5):e97703.

Global gene expression shift during the transition from early neural development to late neuronal differentiation in Drosophila melanogaster.

Cantera R*, Ferreiro MJ, Aransay AM, Barrio R.*

PMID: 24830291


Molecular Oncology. (2014) pii: S1574-7891(14)00079-9.

Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity

Lang V, Pallara C, Zabala A, Lobato-Gil S, Lopitz-Otsoa F, Farrás R, Hjerpe R, Torres-Ramos M, Zabaleta L,  Blattner C, Hay RT, Barrio R, Carracedo A,  Fernandez-Recio J, Rodríguez MS, Aillet F.

PMID: 24816189


J Proteome Res. 13(6):3016-26. doi: 10.1021/pr5001913

Ubiquitin Profiling in Liver Using a Transgenic Mouse with Biotinylated Ubiquitin.

Lectez B, Migotti R, Lee SY, Ramirez J, Beraza N, Mansfield B, Sutherland JD, Martinez-Chantar ML, Dittmar G, Mayor U.

PMID: 24730562


Cell Mol Life Sci. 2014, 71(14):2747-58. doi: 10.1007/s00018-013-1526-7.

Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10.

Lee SY, Ramirez J, Franco M, Lectez B, Gonzalez M, Barrio R, Mayor U.

PMID: 24292889



PLoS Genetics 2013, 9(4): e1003473. doi:10.1371/journal.pgen.1003473 (2013)

Scavenger Receptors Mediate the Role of SUMO and Ftz-f1 in Drosophila Steroidogenesis.

Talamillo A, Herboso L, Pirone L, Pérez C, González M, Sánchez J, Mayor U, Lopitz-Otsoa F, Rodriguez MS, Sutherland JD and Barrio R.

PMID: 23637637





Front Oncol. 2013, Aug 5;3:200. doi: 10.3389/fonc.2013.00200.

PML: Not all about Tumor Suppression

Martin-Martin N, Sutherland JD, Carracedo A.

PMID: 23936764


BMC Genomics. 2012 Sep 15;13(1):483.

Whole transcriptome analysis of a reversible neurodegenerative process in Drosophila reveals potential neuroprotective genes.

Ferreiro MJ, Rodríguez-Ezpeleta N, Pérez C, Hackenberg M, Aransay AM, Barrio R, Cantera R.

PMID: 22978642



Sci. Rep. 2011;1:75

Generation of stable Drosophila cell lines using multicistronic vectors

González M, Martín-Ruíz I, Jiménez S, Pirone L, Barrio R, Sutherland JD

PMID: 22355594

Request our vectors HEREhttp://www.addgene.org/search/?q=sutherland&db=plasmidshttps://www.addgene.org/James_Sutherland/shapeimage_2_link_0



Int J Dev Biol. 2011;55(6):603-11.

Expression of the Scavenger Receptor Class B type I (SR-BI) family in Drosophila melanogaster.

Herboso L, Talamillo A, Pérez C, Barrio R.

PMID: 21948708


PLoS One. 2011;6(6):e21352. Epub 2011 Jun 21.

Efficient allele-specific targeting of LRRK2 R1441 mutations mediated by RNAi.

de Yñigo-Mojado L, Martín-Ruíz I, Sutherland JD.

PMID: 21712955


Biochem J. 2011 Sep 15;438(3):437-45.

Drosophila Sal and Salr are transcriptional repressors.

Sánchez J, Talamillo A, González M, Sánchez-Pulido L, Jiménez S, Pirone L, Sutherland JD, Barrio R.

PMID: 21689070


Biochim Biophys Acta. 2011 Nov-Dec;1809(11-12):660-7. Epub 2011 May 17.

Adenovirus and miRNAs.

Carnero E, Sutherland JD, Fortes P.

PMID: 21621026


Development. 2011 Jan;138(1):107-16. Epub 2010 Nov 29.

Integration of RNA processing and expression level control modulates the function of the Drosophila Hox gene Ultrabithorax during adult development.

de Navas LF, Reed H, Akam M, Barrio R, Alonso CR, Sánchez-Herrero E.

PMID: 21115609





J Biol Chem. 2010 Aug 13;285(33):25841-9. Epub 2010 Jun 18.

Sumoylation modulates the activity of Spalt-like proteins during wing development in Drosophila.

Sánchez J, Talamillo A, Lopitz-Otsoa F, Pérez C, Hjerpe R, Sutherland JD, Herboso L, Rodríguez MS, Barrio R.

PMID: 20562097





Biochem Soc Trans. 2010 Feb;38(Pt 1):54-9.

SUMO and ubiquitin modifications during steroid hormone synthesis and function.

Talamillo A, Martín D, Hjerpe R, Sánchez J, Barrio R.

PMID: 20074035


Int J Dev Biol. 2009;53(8-10):1385-98.

Regulation and function of Spalt proteins during animal development.

de Celis JF, Barrio R.

PMID: 19247946


Biochem Soc Trans. 2008 Oct;36(Pt 5):868-73.

Functional analysis of the SUMOylation pathway in Drosophila.

Talamillo A, Sánchez J, Barrio R.

PMID: 18793153


Development. 2008 May;135(9):1659-68. Epub 2008 Mar 26.

Smt3 is required for Drosophila melanogaster metamorphosis.

Talamillo A, Sánchez J, Cantera R, Pérez C, Martín D, Caminero E, Barrio R.

PMID: 18367553


Dev Biol. 2007 Jun 1;306(1):66-81. Epub 2007 Mar 3.

Characterization of dSnoN and its relationship to Decapentaplegic signaling in Drosophila.

Barrio R, López-Varea A, Casado M, de Celis JF.

PMID: 17434471


Development. 2007 Apr;134(7):1337-46. Epub 2007 Feb 28.

Antagonistic and cooperative actions of the EGFR and Dpp pathways on the iroquois genes regulate Drosophila mesothorax specification and patterning.

Letizia A, Barrio R, Campuzano S.

PMID: 17329358


Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6021-6. Epub 2004 Apr 12.

Regulation of spalt expression in the Drosophila wing blade in response to the Decapentaplegic signaling pathway.

Barrio R, de Celis JF.

PMID: 15079076



Previous Publications