PhD position offered

Project Summary

Rosa Barrio (ORCID: 0000-0002-9663-0669; Researcher ID: F-8712-2011) and her group study posttranslational modifications by members of the ubiquitin-like family (ubiquitin, SUMO, etc) during development, cellular homeostasis and in disease. We study Townes-Brocks syndrome (TBS; OMIM 107480), a developmental disease characterized by limb or digit abnormalities, sensioneural deafness and renal defects, caused by mutations in SALL1. Mutations affect the primary cilium, a complex and dynamic organelle with many roles in development and disease. We are interested on the role of ubiquitin-likes in the regulation of centrosomal and ciliaryhomeostasis, and the development of new technology to explore those questions.

Brief Description of the Research Group

The Barrio Lab offers a creative international atmosphere, with multiple collaborators. Expected training includes CRISPR-Cas9 genome editing, novel proteomics strategies, microscopy, biochemistry and cell biology. Dr. Barrio laboratory is located at CIC bioGUNE (Bilbao, Spain), an institute dedicated to research in Biomedicine, funded in 2004. It offers state-of-the-art equipment and facilities, including technological platforms in genomics, proteomics and structural biology.For more information about the Barrio Lab (research, publications, research centre):

http://personal.cicbiogune.es/rbarrio/

https://www.cicbiogune.es/

Eligibility, required documents and deadlines

Candidates should have a degree in Biology, Biotechnology, Biochemistry, Biomedicine or similar and a Master that allows her/him to access to a doctorate program (300 credits total, at least 60 of them derived from the Master). Candidates should provide: a letter of introduction/interest, an updated CV including grades from degree and master, and names/email addresses of three reference persons. Send this information to rbarrio@cicbiogune.es by the end of September 2021.

Applications will be open in October 2021


Job position description

We are seeking for a highly motivated student with interest in studying the molecular mechanisms underlying a rare disease and the function of cilia. The student will find a collaborative and stimulating atmosphere in an international center with state of the art installations.

Tasks assigned to the new recruitment will include culture processing and analysis of patient-derived primary cells, as well as cells derived from mice modeling the disease. The student will learn techniques of molecular biology (gene editing by CRISPR-Cas9, cloning), biochemistry (protein-protein interactions, immunoprecipitations, proximity proteomics), cell biology (cell culture, immunostainings, fluorescence and confocal microscopy), and genetics (model organisms).

The student will have individual meetings with the supervisor on weekly basis ad will benefit of the advice of a tailored Training Advisory Committee. In addition, the student will have the opportunity to present and discuss her/his research in several forums: weekly laboratory meetings with all the members of the group; monthly CIC bioGUNE PhD students seminar series; regular meetings with local groups; one national congress per year; at least one international congress during her/his PhD. The student will participate of the Training Program organized by CIC bioGUNE, which consist of weekly seminar series with invited national and international speakers on a wide range of current biomedical topics, scientific courses on areas of interest and courses on technology transfer and innovation. The fellows will benefit from continuing education and training in scientific and soft skills, such are state of the art technology, public presentations and scientific writing.